Keizo Takenaga Selected Research

tetraphenylporphine sulfonate (TPPS)

4/2022	Suppression of non-small-cell lung cancer A549 tumor growth by an mtDNA mutation-targeting pyrrole-imidazole polyamide-triphenylphosphonium and a senolytic drug.
10/2021	A linear five-ring pyrrole-imidazole polyamide-triphenylphosphonium conjugate targeting a mitochondrial DNA mutation efficiently induces apoptosis of HeLa cybrid cells carrying the mutation.
6/2021	A PI polyamide-TPP conjugate targeting a mtDNA mutation induces cell death of cancer cells with the mutation.

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Keizo Takenaga Research Topics

Disease

38	Neoplasms (Cancer) 04/2022 - 05/2002
17	Neoplasm Metastasis (Metastasis) 12/2021 - 05/2002
12	Hypoxia (Hypoxemia) 06/2017 - 09/2002
9	Pancreatic Neoplasms (Pancreatic Cancer) 01/2021 - 09/2012
9	Carcinoma (Carcinomatosis) 01/2021 - 05/2002
5	Mitochondrial Diseases (Mitochondrial Disease) 01/2018 - 09/2010
4	Lewis Lung Carcinoma 10/2021 - 10/2003
3	Breast Neoplasms (Breast Cancer) 01/2021 - 07/2003
3	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 01/2014
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2022 - 01/2021
2	Fibrosarcoma 08/2007 - 01/2005
1	Weight Loss (Weight Reduction) 01/2021
1	Obesity 01/2021
1	Body Weight (Weight, Body) 01/2021
1	Inflammation (Inflammations) 01/2020
1	Propofol Infusion Syndrome 01/2018
1	Bacterial Infections (Bacterial Infection) 11/2017
1	Infections 11/2017
1	Colorectal Neoplasms (Colorectal Cancer) 11/2016
1	Necrosis 10/2016
1	Carcinogenesis 12/2012
1	Adenocarcinoma 12/2012
1	Lymphoma (Lymphomas) 06/2012
1	Myeloid Leukemia (Leukemia, Myelocytic) 05/2011
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 05/2011

Drug/Important Bio-Agent (IBA)

20	Mitochondrial DNA (mtDNA)IBA 04/2022 - 09/2002
11	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2021 - 09/2008
9	Proteins (Proteins, Gene)FDA Link 01/2021 - 07/2002
6	Pharmaceutical PreparationsIBA 04/2022 - 01/2010
4	Nylons (Nylon)IBA 04/2022 - 06/2021
4	Messenger RNA (mRNA)IBA 01/2020 - 10/2003
4	DNA (Deoxyribonucleic Acid)IBA 11/2017 - 10/2010
3	tetraphenylporphine sulfonate (TPPS)IBA 04/2022 - 06/2021
3	Peptides (Polypeptides)IBA 01/2021 - 01/2013
3	Small Interfering RNA (siRNA)IBA 01/2020 - 01/2014
3	Interleukin-33IBA 01/2020 - 11/2016
3	Calcium-Binding ProteinsIBA 01/2015 - 07/2002
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2005 - 09/2002
2	imidazoleIBA 04/2022 - 12/2021
2	triphenylphosphoniumIBA 04/2022 - 12/2021
2	PyrrolesIBA 04/2022 - 12/2021
2	NucleotidesIBA 10/2021 - 11/2017
2	AdipoRonIBA 01/2021 - 01/2018
2	NADH DehydrogenaseIBA 01/2021 - 11/2017
2	Hypoglycemic Agents (Hypoglycemics)IBA 01/2021 - 01/2018
2	Adiponectin ReceptorsIBA 01/2021 - 01/2018
2	CytokinesIBA 01/2020 - 06/2003
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2017 - 05/2002
2	Gemcitabine FDA Link 03/2013 - 09/2012
2	AntioxidantsIBA 03/2013 - 02/2013
2	Oxygen (Dioxygen)IBA 12/2005 - 09/2002
1	SenotherapeuticsIBA 04/2022
1	Histones (Histone)IBA 12/2021
1	Adenosine Triphosphate (ATP)IBA 12/2021
1	Liposomes (Liposome)IBA 01/2021
1	LeptinIBA 01/2021
1	Methionine (L-Methionine)FDA Link 01/2021
1	ChemokinesIBA 01/2020
1	BiguanidesIBA 01/2018
1	CaspasesIBA 01/2018
1	Propofol (Diprivan)FDA LinkGeneric 01/2018
1	Superoxides (Superoxide)IBA 01/2018
1	Metformin (Glucophage)FDA LinkGeneric 01/2018
1	p38 Mitogen-Activated Protein KinasesIBA 01/2018
1	AdiponectinIBA 01/2018
1	Phenformin (Fenformin)IBA 01/2018
1	SurvivinIBA 06/2017
1	Death Domain ReceptorsIBA 06/2017
1	TNF-Related Apoptosis-Inducing LigandIBA 06/2017
1	ElementsIBA 06/2017
1	FITC-annexin A5IBA 10/2016
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 10/2016
1	Lidocaine (Xylocaine)FDA LinkGeneric 10/2016
1	Mepivacaine (Carbocaine)FDA LinkGeneric 10/2016
1	Local AnestheticsIBA 10/2016
1	Caspase 9IBA 10/2016
1	Caspase 3 (Caspase-3)IBA 10/2016
1	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 10/2016
1	Angiogenesis InhibitorsIBA 01/2015
1	Ethanol (Ethyl Alcohol)IBA 01/2015
1	AminopeptidasesIBA 01/2015
1	ginger extractIBA 01/2015
1	Leu Transfer RNAIBA 02/2014
1	Lys Transfer RNAIBA 02/2014
1	ebselenIBA 02/2013
1	Acetylcysteine (Siran)FDA LinkGeneric 02/2013
1	Interleukin-6 (Interleukin 6)IBA 01/2013
1	EnzymesIBA 01/2013
1	fusicoccinIBA 09/2012
1	ISIR-042IBA 09/2012
1	LactatesIBA 06/2012
1	Hypoxia-Inducible Factor 1IBA 02/2012
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 02/2012
1	sodium bisulfide (NaHS)IBA 02/2012
1	sodium sulfideIBA 02/2012
1	cyclopamineIBA 05/2011

Therapy/Procedure

7	Therapeutics 04/2022 - 12/2005
1	Fat-Restricted Diet (Diet, Fat Restricted) 01/2021
1	Intravenous Administration 01/2021
1	Oral Administration 01/2018